The operational control strategy of a refrigeration plant directly impacts its annual energy efficiency. Conventional control logic, based on static design conditions or time-scheduled fixed parameters, cannot effectively adapt to continuous fluctuations in cooling load and meteorological conditions. This paper employs a model-based Dymola environment to develop a fullsystem model of a high-efficiency refrigeration plant and proposes a dynamic control strategy driven by hourly cooling load and outdoor meteorological parameters. Based on the hourly cooling load profile of a public building in a hot-summer warm-winter climate zone, the proposed strategy is simulated and compared against a conventional baseline. The results indicate that the proposed strategy achieves an energy efficiency ratio (EER) of 6.02 over the cooling season, representing a 19.4% improvement compared to the baseline strategy. The proposed methodology offers a practical reference for control strategy optimization in chiller plants of large public facilities with fluctuating cooling loads, such as airports and shopping malls.

Safe operation of biosafety laboratories requires directional airflow and stable pressure gradients to contain pathogenic aerosols. However, door operations between the core and buffer rooms frequently disrupt this balance, inducing transient pressure disturbances. Conventional PI control often responds inadequately to such rapid transients, which can lead to airflow reversal and compromise biosafety. This study develops a Modelicabased two-zone transient differential pressure regulation model for the core and buffer rooms and proposes a coordinated control strategy that integrates feedforward compensation with an integral-freezing mechanism. During door opening, the feedforward mechanism adjusts the exhaust airflow, rapidly increasing the doorway air mass flow rate to 0.12–0.14 kg/s. This establishes a directional airflow barrier (velocity ≥ 0.2 m/s), thereby reducing the risk of leakage during personnel transit. By freezing the PI integral term during the door-open phase and applying feedforward exhaust compensation upon closure, the proposed strategy restricts the maximum pressure undershoot during door closure to −17 Pa (against the −15 Pa design setpoint), compared to −24 Pa under conventional PI control. The pressure recovery time is also reduced from 48.3 s to 13.6 s. These findings provide a simulation-based basis for improving the dynamic containment of high-level biosafety laboratories under transient disturbances.